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Following dichotomization of ALT responders based on a median 12.9% decrease from baseline, we found that ALT responders were younger in age and did not have severe diabetes compared with ALT non-responders

Temporarily lowering the dose then ramping back up

While incretins have significant and widespread impacts on different organs, their actions are not long-lasting

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Furthermore, when we examined the expression of genes encoding enzymes that act as metabolic gatekeepers in CD4 + T cells, we found a BHD-induced upregulation of Cpt1 (fatty acid oxidation), Got1 (amino acid metabolism), Ndufs8 (OXPHOS), Sdha , Sdhb , Sdhc (TCA cycle) and Txnrd1 (redox balance) (Fig